Axon guidance: Starting and stopping with Slit
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چکیده
منابع مشابه
Axon guidance: Starting and stopping with Slit
As developing axons navigate, they exhibit various behaviours: extending and branching, pausing, changing direction, retracting. Now, the Slit protein has been discovered to have striking positive and negative effects on axon growth and guidance.
متن کاملThe Middle and the End Slit Brings Guidance and Branching Together in Axon Pathway Selection
early and direct demonstration of this came from studies on the vertebrate forebrain, where Pini (1993) showed by in vitro coculture of neural explants that a diffusible activity from the midline septum can repel axons growing out from the olfactory bulb (Figure 1A). The presence of repellents at the midline was also indicated by genetic analysis in Drosophila where, in the roundabout (robo A t...
متن کاملSlit Branches Out A Secreted Protein Mediates Both Attractive and Repulsive Axon Guidance
grow to the midline because attractive molecules such as netrins are expressed there. Midline repulsive activi-Slit is a large, modular extracellular matrix protein con-ties may also be necessary, however, to prevent longitu-taining four arrays of leucine-rich repeat (LRR) se-dinal axons that express attractive netrin receptors from quences, followed by a string of epidermal growth factor cross...
متن کاملSlit proteins regulate distinct aspects of retinal ganglion cell axon guidance within dorsal and ventral retina.
An early step in the formation of the optic pathway is the directed extension of retinal ganglion cell (RGC) axons into the optic fiber layer (OFL) of the retina in which they project toward the optic disc. Using analysis of knock-out mice and in vitro assays, we found that, in the mammalian retina, Slit1 and Slit2, known chemorepellents for RGC axons, regulate distinct aspects of intraretinal ...
متن کاملChimeric Axon Guidance Receptors The Cytoplasmic Domains of Slit and Netrin Receptors Specify Attraction versus Repulsion
Frazzled (Fra) is the DCC-like Netrin receptor in Drosophila that mediates attraction; Roundabout (Robo) is a Slit receptor that mediates repulsion. Both ligands are expressed at the midline; both receptors have related structures and are often expressed by the same neurons. To determine if attraction versus repulsion is a modular function encoded in the cytoplasmic domain of these receptors, w...
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ژورنال
عنوان ژورنال: Current Biology
سال: 1999
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(99)80274-7